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1

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

Naruto Taira, Kojiro Shimozuma, Takeru Shiroiwa, Shozo Ohsumi, Katsumasa Kuroi, Shigehira Saji, Mitsue Saito, Shigemichi Iha, Takanori Watanabe, Noriyuki Katsumata

Journal:

Breast Cancer Research and Treatment

Year:

2011

Language:

english

File:

PDF, 215 KB

english, 2011

2

Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status—A meta-analysis

Reiko Suzuki, Nicola Orsini, Shigehira Saji, Timothy J. Key, Alicja Wolk

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 344 KB

english, 2009

3

Concomitant polypharmacy is associated with irinotecan-related adverse drug reactions in patients with cancer

Sasaki, Tetsuya, Fujita, Ken-ichi, Sunakawa, Yu, Ishida, Hiroo, Yamashita, Keishi, Miwa, Keisuke, Saji, Shigehira, Kato, Yasuhisa, Sasaki, Yasutsuna

Journal:

International Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 203 KB

english, 2013

4

Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with postmenopausal estrogen receptor-positive advanced breast cancer: a subgroup analysis of the JBCRG-C06 Safari study

Kawaguchi, Hidetoshi, Masuda, Norikazu, Nakayama, Takahiro, Aogi, Kenjiro, Anan, Keisei, Ito, Yoshinori, Ohtani, Shoichiro, Sato, Nobuaki, Saji, Shigehira, Takano, Toshimi, Tokunaga, Eriko, Nakamura,

Journal:

Current Medical Research and Opinion

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

5

Development of Breast Cancer Therapy: Biomarker-Driven and Response-Guided Approaches in a Neoadjuvant Setting

Toi, Masakazu, Masuda, Norikazu, Ishiguro, Hiroshi, Saji, Shigehira, Ohno, Shinji, Chow, Louis W.C.

Journal:

The International Journal of Biological Markers

Year:

2015

Language:

english

File:

PDF, 669 KB

english, 2015

6

Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network

Kiso, Marina, Tanaka, Sunao, Saji, Shigehira, Toi, Masakazu, Sato, Fumiaki

Journal:

International Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

7

Clinical usefulness of high-dose toremifene in patients relapsed on treatment with an aromatase inhibitor

Yutaka Yamamoto, Norikazu Masuda, Tohru Ohtake, Hiroko Yamashita, Shigehira Saji, Izo Kimijima, Yoshio Kasahara, Takashi Ishikawa, Masataka Sawaki, Yasuo Hozumi, Hirotaka Iwase

Journal:

Year:

2010

Language:

english

File:

PDF, 209 KB

english, 2010

8

Fuel, electricity, ER and HER2—a hybrid-car model of breast cancer

Saji, Shigehira, Sato, Fumiaki, Ueno, Naoto T.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

9

A Case of Squamous Cell Carcinoma of Unknown Primary that Responded to the Multi-Tyrosine Kinase Inhibitor Lenvatinib

Kimura-Tsuchiya, Reiko, Sasaki, Eisaku, Nakamura, Izumi, Suzuki, Satoshi, Kawana, Satoshi, Okouchi, Chiyo, Fukushima, Toshihiko, Hashimoto, Yuko, Suzuki, Shinichi, Saji, Shigehira

Journal:

Case Reports in Oncology

Year:

2018

Language:

english

File:

PDF, 779 KB

english, 2018

10

Neoadjuvant exemestane or exemestane plus docetaxel and cyclophosphamide tailored by clinicopathological response to 12 weeks' exemestane exposure in patients with estrogen receptor‐positive breast cancer: A multicenter, open‐label, phase II study

Sato, Nobuaki, Masuda, Norikazu, Morimoto, Takashi, Ueno, Takayuki, Kanbayashi, Chizuko, Kaneko, Koji, Yasojima, Hiroyuki, Saji, Shigehira, Sasano, Hironobu, Morita, Satoshi, Ohno, Shinji, Toi, Masaka

Journal:

Cancer Medicine

Year:

2019

Language:

english

File:

PDF, 540 KB

english, 2019

11

Weekly schedule of docetaxel in breast cancer: Evaluation of response and toxicity

Katsumasa Kuroi, Hiroko Bando, Shigehira Saji, Masakazu Toi

Journal:

Year:

2003

Language:

english

File:

PDF, 509 KB

english, 2003

12

Immunohistochemical Detection of Breast Cancer Stem Cells in Hormone Receptor-Positive Breast Cancer and Their Role in Response to Endocrine Therapy and Clinical Outcome

Hashimoto, Kenji, Shimizu, Chikako, Tsuda, Hitoshi, Saji, Shigehira, Osaki, Akihiko, Shigekawa, Takashi, Aogi, Kenjiro

Journal:

Year:

2012

Language:

english

File:

PDF, 620 KB

english, 2012

13

Association of Positive EBAG9 Immunoreactivity With Unfavorable Prognosis in Breast Cancer Patients Treated With Tamoxifen

Ijichi, Nobuhiro, Shigekawa, Takashi, Ikeda, Kazuhiro, Miyazaki, Toshiaki, Horie-Inoue, Kuniko, Shimizu, Chikako, Saji, Shigehira, Aogi, Kenjiro, Tsuda, Hitoshi, Osaki, Akihiko, Saeki, Toshiaki, Inoue

Journal:

Clinical Breast Cancer

Year:

2013

Language:

english

File:

PDF, 551 KB

english, 2013

14

A phase I/II pharmacokinetics/pharmacodynamics study of irinotecan combined with S−1 for recurrent/metastatic breast cancer in patients with selected UGT1A1 genotypes (the JBCRG-M01 study)

Ishiguro, Hiroshi, Saji, Shigehira, Nomura, Shogo, Tanaka, Sunao, Ueno, Takayuki, Onoue, Masahide, Iwata, Hiroji, Yamanaka, Takeharu, Sasaki, Yasutsuna, Toi, Masakazu

Journal:

Cancer Medicine

Year:

2017

Language:

english

File:

PDF, 326 KB

english, 2017

15

Impact of physiological hormonal fluctuations on 18F-fluorodeoxyglucose uptake in breast cancer

Miyake, Kanae K., Nakamoto, Yuji, Saji, Shigehira, Sugie, Tomoharu, Kurihara, Kensuke, Kanao, Shotaro, Ikeda, Debra M., Toi, Masakazu, Togashi, Kaori

Journal:

Breast Cancer Research and Treatment

Year:

2018

Language:

english

File:

PDF, 1.21 MB

english, 2018

16

Potential Clinical Applications of Matrix Metalloproteinase Inhibitors and their Future Prospects

Li, Wenzhao, Saji, Shigehira, Sato, Fumiaki, Noda, Makoto, Toi, Masakazu

Journal:

The International Journal of Biological Markers

Year:

2013

Language:

english

File:

PDF, 133 KB

english, 2013

17

EL17Recent progress of molecular target therapy for breast cancer

Saji, Shigehira

Journal:

Annals of Oncology

Year:

2017

Language:

english

File:

PDF, 47 KB

english, 2017

18

Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes

Nobuyuki Yoshida, Yoko Omoto, Akio Inoue, Hidetaka Eguchi, Yasuhito Kobayashi, Masafumi Kurosumi, Shigehira Saji, Kimito Suemasu, Tomoki Okazaki, Kei Nakachi, Toshiro Fujita, Shin-ichi Hayashi

Journal:

Year:

2004

Language:

english

File:

PDF, 460 KB

english, 2004

19

Association of Double-Positive FOXA1 and FOXP1 Immunoreactivities with Favorable Prognosis of Tamoxifen-Treated Breast Cancer Patients

Ijichi, Nobuhiro, Shigekawa, Takashi, Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Shimizu, Chikako, Saji, Shigehira, Aogi, Kenjiro, Tsuda, Hitoshi, Osaki, Akihiko, Saeki, Toshiaki, Inoue, Satoshi

Journal:

Hormones and Cancer

Year:

2012

Language:

english

File:

PDF, 502 KB

english, 2012

20

Progesterone receptor expression in proliferating cancer cells of hormone-receptor-positive breast cancer

Ueno, Takayuki, Saji, Shigehira, Chiba, Tomohiro, Kamma, Hiroshi, Isaka, Hirotsugu, Itoh, Hiroki, Imi, Kentaro, Miyamoto, Kaisuke, Tada, Manami, Sasano, Hironobu, Toi, Masakazu, Imoto, Shigeru

Journal:

Year:

2018

Language:

english

File:

PDF, 2.82 MB

english, 2018

21

Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7

Suga, Junko, Izumiyama, Keiko, Tanaka, Nobuyuki, Saji, Shigehira

Journal:

Biochemistry and Biophysics Reports

Year:

2018

Language:

english

File:

PDF, 1.12 MB

english, 2018

22

CYP2D6 Genotype–Guided Tamoxifen Dosing in Hormone Receptor–Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study

Tamura, Kenji, Imamura, Chiyo K., Takano, Toshimi, Saji, Shigehira, Yamanaka, Takeharu, Yonemori, Kan, Takahashi, Masato, Tsurutani, Junji, Nishimura, Reiki, Sato, Kazuhiko, Kitani, Akira, Ueno, Naoto

Journal:

Journal of Clinical Oncology

Year:

2019

File:

PDF, 780 KB

2019

23

Aromatase inhibitors and other novel agents in breast cancer treatment

Saji, Shigehira, Toi, Masakazu

Journal:

Expert Opinion on Emerging Drugs

Year:

2002

Language:

english

File:

PDF, 306 KB

english, 2002

24

ISY-4-2Overcoming endocrine therapy resistance in breast cancer, a cat and mouse game?

Saji, Shigehira, Kimura-Tsuchiya, Reiko, Sasaki, Eisaku

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 41 KB

english, 2016

25

The Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer Screening and Diagnosis, 2018 Edition

Uematsu, Takayoshi, Nakashima, Kazutaka, Kikuchi, Mari, Kubota, Kazunori, Suzuki, Akihiko, Nakano, Shogo, Hirokaga, Kouichi, Yamaguchi, Ken, Saji, Shigehira, Iwata, Hiroji

Journal:

Year:

2019

Language:

english

File:

PDF, 664 KB

english, 2019

26

Trastuzumab, pertuzumab, and eribulin mesylate versus trastuzumab, pertuzumab, and a taxane as a first-line or second-line treatment for HER2-positive, locally advanced or metastatic breast cancer: study protocol for a randomized controlled, non-inferiority, phase III trial in Japan (JBCRG-M06/EMERALD)

Yamashita, Toshinari, Masuda, Norikazu, Saji, Shigehira, Araki, Kazuhiro, Ito, Yoshinori, Takano, Toshimi, Takahashi, Masato, Tsurutani, Junji, Koizumi, Kei, Kitada, Masahiro, Kojima, Yasuyuki, Sagara

Journal:

Year:

2020

File:

PDF, 955 KB

2020

27

Overexpression of MDM2 in MCF-7 Promotes Both Growth Advantage and p53 Accumulation in Response to Estradiol

Shigehira Saji, Shigeru Nakashima, Shin-ichi Hayashi, Masakazu Toi, Shigetoyo Saji, Yoshinori Nozawa

Journal:

Year:

1999

Language:

english

File:

PDF, 1.50 MB

english, 1999

28

Evaluating the 21-gene assay Recurrence Score®as a predictor of clinical response to 24

Ueno, Takayuki, Masuda, Norikazu, Yamanaka, Takeharu, Saji, Shigehira, Kuroi, Katsumasa, Sato, Nobuaki, Takei, Hiroyuki, Yamamoto, Yutaka, Ohno, Shinji, Yamashita, Hiroko, Hisamatsu, Kazufumi, Aogi, K

Journal:

International Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 261 KB

english, 2014

29

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

Takada, Masahiro, Kataoka, Akemi, Toi, Masakazu, Bando, Hiroko, Toyama, Kazumi, Horiguchi, Shinichiro, Ueno, Takayuki, Linder, Stig, Saji, Shigehira, Hayashi, Yukiko, Funata, Nobuaki, Kinoshita, Junko

Journal:

International Journal of Oncology

Year:

2004

Language:

english

File:

PDF, 2.37 MB

english, 2004

30

A Phase I Study of Infusional 5-Fluorouracil, Leucovorin, Oxaliplatin and Irinotecan in Japanese Patients with Advanced Colorectal Cancer Who Harbor UGT1A11/1,1/6 or 1/28

Sunakawa, Yu, Fujita, Ken-ichi, Ichikawa, Wataru, Ishida, Hiroo, Yamashita, Keishi, Araki, Kazuhiro, Miwa, Keisuke, Kawara, Kaori, Akiyama, Yuko, Yamamoto, Wataru, Nagashima, Fumio, Saji, Shigehira, S

Journal:

Year:

2012

Language:

english

File:

PDF, 201 KB

english, 2012

31

The long and winding road for overcoming resistance to hormone therapy in breast cancer

Saji, Shigehira

Journal:

Year:

2018

Language:

english

File:

PDF, 788 KB

english, 2018

32

Impact of clinical response to neoadjuvant endocrine therapy on patient outcomes: a follow-up study of JFMC34-0601 multicentre prospective neoadjuvant endocrine trial

Ueno, Takayuki, Saji, Shigehira, Masuda, Norikazu, Kuroi, Katsumasa, Sato, Nobuaki, Takei, Hiroyuki, Yamamoto, Yutaka, Ohno, Shinji, Yamashita, Hiroko, Hisamatsu, Kazufumi, Aogi, Kenjiro, Iwata, Hiroj

Journal:

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

33

Alcohol intake and risk of breast cancer defined by estrogen and progesterone receptor status—A meta-analysis of epidemiological studies

Reiko Suzuki, Nicola Orsini, Laura Mignone, Shigehira Saji, Alicja Wolk

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 163 KB

english, 2008

34

MDM2in breast cancer

Masakazu Toi, Shigehira Saji, Akio Suzuki, Yutaka Yamamoto, Takeshi Tominaga

Journal:

Year:

1997

Language:

english

File:

PDF, 444 KB

english, 1997

35

Aromatase and aromatase inhibitors

Masakazu Toi, Hiroko Bando, Shigehira Saji

Journal:

Year:

2001

Language:

english

File:

PDF, 342 KB

english, 2001

36

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos P

Journal:

Year:

2010

Language:

english

File:

PDF, 393 KB

english, 2010

37

Impact of body mass index on breast cancer in accordance with the life-stage of women

Suzuki, Reiko, Saji, Shigehira, Toi, Masakazu

Journal:

Frontiers in Oncology

Year:

2012

Language:

english

File:

PDF, 291 KB

english, 2012

38

Molecular diagnostics for precision medicine in breast cancer treatment: what does the future hold?

Saji, Shigehira, Kimura-Tsuchiya, Reiko, Sasaki, Eisaku

Journal:

Year:

2016

Language:

english

File:

PDF, 366 KB

english, 2016

39

Dose-Finding Phase I and Pharmacokinetic Study of Capecitabine (Xeloda) in Combination with Epirubicin and Cyclophosphamide (CEX) in Patients with Inoperable or Metastatic Breast Cancer

Saji, Shigehira, Toi, Masakazu, Morita, Satoshi, Iwata, Hiroji, Ito, Yoshinori, Ohno, Shinji, Kobayashi, Tadashi, Hozumi, Yasuo, Sakamoto, Junichi

Journal:

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

40

Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status—A prospective cohort study among Swedish women

Reiko Suzuki, Tove Rylander-Rudqvist, Weimin Ye, Shigehira Saji, Herman Adlercreutz, Alicja Wolk

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 131 KB

english, 2008

41

Quantitative Analysis of Estrogen Receptor Proteins in Rat Mammary Gland 1

Saji, Shigehira, Sakaguchi, Hideki, Andersson, Sandra, Warner, Margaret, Gustafsson, Jan-Åke

Journal:

Year:

2001

Language:

english

File:

PDF, 747 KB

english, 2001

42

Randomized phase II study of three doses of oral TAS-108 in postmenopausal patients with metastatic breast cancer

Hideo Inaji, Hiroji Iwata, Takahiro Nakayama, Naohito Yamamoto, Yasuyuki Sato, Yutaka Tokuda, Kenjiro Aogi, Shigehira Saji, Kenichi Watanabe, Tsuyoshi Saito, Masayuki Yoshida, Nobuaki Sato, Toshiaki S

Journal:

Year:

2012

Language:

english

File:

PDF, 146 KB

english, 2012

43

A phase II study of lapatinib for brain metastases in patients with HER2-overexpressing breast cancer following trastuzumab based systemic therapy and cranial radiotherapy: subset analysis of Japanese patients

Iwata, Hiroji, Narabayashi, Masaru, Ito, Yoshinori, Saji, Shigehira, Fujiwara, Yasuhiro, Usami, Shigeyuki, Katsura, Koichi, Sasaki, Yasutsuna

Journal:

International Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

44

Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy

Ueno, Takayuki, Saji, Shigehira, Sugimoto, Masahiro, Masuda, Norikazu, Kuroi, Katsumasa, Sato, Nobuaki, Takei, Hiroyuki, Yamamoto, Yutaka, Ohno, Shinji, Yamashita, Hiroko, Hisamatsu, Kazufumi, Aogi, K

Journal:

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

45

Differential Involvement of Autophagy and Apoptosis in Response to Chemoendocrine and Endocrine Therapy in Breast Cancer: JBCRG-07TR

Ueno, Takayuki, Masuda, Norikazu, Kamigaki, Shunji, Morimoto, Takashi, Saji, Shigehira, Imoto, Shigeru, Sasano, Hironobu, Toi, Masakazu

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 2.16 MB

english, 2019

46

Intensive vs. Standard Post-Operative Surveillance in High-Risk Breast Cancer Patients (INSPIRE): Japan Clinical Oncology Group Study JCOG1204

Hojo, Takashi, Masuda, Norikazu, Mizutani, Tomonori, Shibata, Taro, Kinoshita, Takayuki, Tamura, Kenji, Hara, Fumikata, Fujisawa, Tomomi, Inoue, Kenichi, Saji, Shigehira, Nakamura, Kenichi, Fukuda, Ha

Journal:

Japanese Journal of Clinical Oncology

Year:

2015

Language:

english

File:

PDF, 238 KB

english, 2015

47

Differential Involvement of Autophagy and Apoptosis in Response to Chemoendocrine and Endocrine Therapy in Breast Cancer: JBCRG-07TR

Ueno, Takayuki, Masuda, Norikazu, Kamigaki, Shunji, Morimoto, Takashi, Saji, Shigehira, Imoto, Shigeru, Sasano, Hironobu, Toi, Masakazu

Journal:

International Journal of Molecular Sciences

Year:

2019

File:

PDF, 2.16 MB

2019

48

Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011

Kurebayashi, Junichi, Miyoshi, Yasuo, Ishikawa, Takashi, Saji, Shigehira, Sugie, Tomoharu, Suzuki, Takashi, Takahashi, Shunji, Nozaki, Miwako, Yamashita, Hiroko, Tokuda, Yutaka, Nakamura, Seigo

Journal:

Year:

2015

Language:

english

File:

PDF, 473 KB

english, 2015

49

Genomic tumor evolution of breast cancer

Sato, Fumiaki, Saji, Shigehira, Toi, Masakazu

Journal:

Year:

2016

Language:

english

File:

PDF, 536 KB

english, 2016

50

Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial

Mittendorf, Elizabeth A, Zhang, Hong, Barrios, Carlos H, Saji, Shigehira, Jung, Kyung Hae, Hegg, Roberto, Koehler, Andreas, Sohn, Joohyuk, Iwata, Hiroji, Telli, Melinda L, Ferrario, Cristiano, Punie,

Journal:

Lancet (London, England)

Year:

2020

File:

PDF, 658 KB

2020

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